6,6-Dihalopenicillanic acid 1,1-dioxides

Details 6,6-Dihalopenicillanic acid 1,1-dioxides 6,6-Dihalopenicillanic acid 1,1-dioxides

1986-08-05

1988-08-09

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514192, C07D49900, A61K 31425

Patent

active

047629207

ABSTRACT:
A process for the preparation of penicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo, which comprises oxidation of a 6,6-dihalopenicillanic acid, or an ester thereof readily hydrolyzable in vivo, to the corresponding 6,6-dihalopenicillanic acid 1,1-dioxide or ester thereof, followed by dehalogenation (e.g. by hydrogenolysis). The 6,6-dihalopenicillanic acid 1,1-dioxides and esters thereof readily hydrolyzable in vivo are novel intermediates. Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are known compounds which are useful as beta-lactamase inhibitors and for enhancing the effectiveness of certain beta-lactam antibiotics (e.g. the penicillins) in the treatement of bacterial infections in mammals, particularly humans.

REFERENCES:
patent: 4234579 (1980-11-01), Barth et al.
patent: 4420426 (1983-12-01), Moore et al.

Affiliated with

Also associated with

Rating

6,6-Dihalopenicillanic acid 1,1-dioxides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6,6-Dihalopenicillanic acid 1,1-dioxides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6,6-Dihalopenicillanic acid 1,1-dioxides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-919424