6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tet

Details 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tet 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tet

1989-02-07

1990-05-08

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142315, 514311, 514315, 544 62, 544128, 544363, 548153, 548159, C07D41700, C07D41300, C07D21560, C07D21538

Patent

active

049238612

ABSTRACT:
Novel 6-[2-[2-(substituted amino)-3-quinolinyl]-ethenyl and ethyl]tetrahydro-4-hydroxypyran-2-ones and/or oxides and the corresponding dihydroxy ring opened acids and esters are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are thus useful hypolipidemic and hypocholesterolemic agents.

REFERENCES:
patent: 4761419 (1988-08-01), Picard et al.

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