6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives

Details 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives

1974-04-10

1986-04-29

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549354, C07D31312, A61K 31335

Patent

active

045857881

ABSTRACT:
6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula ##STR1## are prepared by multi-step sequences. X is C.dbd.O, CHCl, CHBr, CH.sub.2 or CHOR.sup.4 ; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR.sup.5, CH.sub.2 OR.sup.5, CONR.sub.2.sup.5 or CONHOR.sup.5 ; and R.sup.1 -R.sup.5 are hydrogen or alkyl of 1 to 4 carbon atoms.
These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

REFERENCES:
patent: 3702852 (1972-11-01), Yale et al.
patent: 3714201 (1973-01-01), Yale et al.
patent: 3758528 (1973-09-01), Malen et al.

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