6,11-bridged erythromycin derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 72, 536 74, 536 185, A61K 3170, C07H 100, C07H 1708

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active

060461713

ABSTRACT:
Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

REFERENCES:
patent: 4990602 (1991-02-01), Morimoto et al.
patent: 5403923 (1995-04-01), Kashimura et al.
patent: 5444051 (1995-08-01), Agouridas et al.
patent: 5527780 (1996-06-01), Agouridas et al.
Journal of Antibiotics, vol. 37. No. 2 (1984), pp. 187-189, Moritmoto, et al., "Chemical Modification of Erythromycins. I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A".
Journal of Antibiotics, vol. 43, No. 3 (1990), pp. 286-292, Moritmoto, et al., "Chemical Modification of Erythromycins. II. Synthesis and Antibacterial Activity of O-Alkl Derivatives of Erythromycin A".

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