6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid

Details 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid

1979-12-31

1981-11-17

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, 260239A, C07D49904

Patent

active

043010741

ABSTRACT:
Disclosed are 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R is, inter alia, hydrogen, --OR, --SR, --NR.sub.2, alkyl, aryl, aralkyl, or heterocylcyl; n is 0 or 1; when n=1 R is as defined but not --SR. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4182711 (1980-01-01), Ueda et al.

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