Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-10-10
1981-04-07
Morgenstern, Norman
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602391, 2602452R, 424244, 424246, 4242484, 42424851, 424249, 424250, 424256, 424270, 424271, 424269, A61K 3143, C07D49944
Patent
active
042606187
ABSTRACT:
Disclosed are 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R is, inter alia, hydrogen, --OR, --SR, --NR.sub.2, alkyl, aryl, aralkyl, or heterocylcyl; n is 0 or 1; when n=1 R is as defined but not --SR. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 4070477 (1978-01-01), Ernest et al.
patent: 4123539 (1978-10-01), Di Ninno et al.
Arno James A.
Clarke Vera C.
Levitt Julian S.
Merck & Co. , Inc.
Morgenstern Norman
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