6-[1-hydroxyethyl]-2-SR.sup.8 -1-methyl-1-carbadethiapen-2-em-3-

Details 6-[1-hydroxyethyl]-2-SR.sup.8 -1-methyl-1-carbadethiapen-2-em-3- 6-[1-hydroxyethyl]-2-SR.sup.8 -1-methyl-1-carbadethiapen-2-em-3-

1984-04-23

1987-09-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, A61K 3140

Patent

active

046969233

ABSTRACT:
Disclosed are antibiotic 6-[1-hydroxyethyl]-2-SR.sup.8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids and their pharmaceutically acceptable salts and esters (I): ##STR1## wherein: R.sup.8 is ##STR2## and ##STR3## wherein: R.sup.8 is ##STR4## and wherein n and m are independently selected from 0, 1, 2, 3, 4 and 5; X is --NR; and Y is --R, or --NRR; and wherein R is independently selected from hydrogen, alkyl, alkenyl, alkynyl, (having 1-6 carbon atoms); cycloalkyl and cycloalkenyl (having 3-6 carbon atoms); and heterocyclyl, heteroaryl (having 3-6 ring atoms, one or more of which is N, O or S).

REFERENCES:
patent: 4232036 (1980-11-01), Christensen et al.
patent: 4309346 (1982-06-01), Christensen et al.
patent: 4383946 (1983-05-01), Christensen et al.
patent: 4552873 (1985-11-01), Miyadera et al.

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