Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-10-05
1985-10-01
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
2602452T, 2602452R, C07D48704, A61K 3140
Patent
active
045445575
ABSTRACT:
Disclosed is the antibiotic 6-(1-hydroxyethyl)-2-substituted-thio-3-tetrazolyl-1-carbadethiapen-2-em and its pharmaceutically acceptable salts (I): ##STR1## wherein Z is C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3 alkylguanidino, C.sub.1 -C.sub.3 alkylamidino, or heterocycloalkyl and, M=H, a synthetically useful cation, or pharmaceutically acceptable cation. Such compounds as well as their pharmaceutically acceptable salts are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; novel intermediates; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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Andrus W. Alexander
Christensen Burton G.
Heck James V.
Arther Thomas E.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rizzo Nicholas S.
Szura Daniel T.
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