6-(1-hydroxyethyl)-2-(2-amin oethylthio)-1,1-disubstituted-1-car

Details 6-(1-hydroxyethyl)-2-(2-amin oethylthio)-1,1-disubstituted-1-car 6-(1-hydroxyethyl)-2-(2-amin oethylthio)-1,1-disubstituted-1-car

1982-07-13

1986-04-15

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

514210, C07D48704, A61K 3140

Patent

active

045826439

ABSTRACT:
Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen-2-e m-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, substituted and unsubstituted alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the spiro substituent formed by the joinder of R.sup.1 and R.sup.2.

REFERENCES:
patent: 4194047 (1980-03-01), Christensen et al.
patent: 4206219 (1980-06-01), Christensen et al.
patent: 4218462 (1980-08-01), Christensen et al.
patent: 4312871 (1982-06-01), Christensen et al.

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