6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic

Details 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic

1981-01-08

1983-02-08

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2602452T, 424263, 424269, 424270, C09D48704, H61K 3140

Patent

active

043729657

ABSTRACT:
Disclosed are S-oxides of 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein: n is 1 or 2; and R.sup.1, R.sup.6, R.sup.7 and R.sup.8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4123547 (1978-10-01), Christensen et al.
patent: 4150145 (1979-04-01), Christensen et al.
patent: 4181733 (1980-01-01), Christensen et al.
patent: 4218462 (1980-08-01), Christensen et al.
patent: 4232036 (1980-11-01), Christensen et al.
patent: 4341791 (1982-07-01), Christensen et al.

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