6-0-Substituted antibacterial erythromycin ketolides and methods

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 74, 514 29, C07H 1708, A61K 3170

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active

060281812

ABSTRACT:
Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

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Agouridas et al. (X), "Synthesis and Antibacterial Activity of Ketolides (6-0-Methyl-3-oxoerythromycin Derivatives): A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens," J. Medicinal Chemistry, 41(21), 4080-4100 (Oct. 8, 1998).

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