5T4 antigen from human trophoblasts

Details 5T4 antigen from human trophoblasts 5T4 antigen from human trophoblasts

1993-08-17

1999-02-09

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4242041, 530350, A61K 3900, A61K 3938, C07K 100, C07K 1400

Patent

active

058690530

ABSTRACT:
A new glycoprotein 5T4 has been identified in human trophoblast. The antigen and fragments thereof and, more particularly, antibodies that recognise the antigen or fragments thereof are of value in relation to cancer diagnosis and treatment, particularly for the routine screening of cervical smears.

REFERENCES:
patent: 4558035 (1985-12-01), Johnson
Stern et al., J. Immunol. (1986) 137(5):1604-1609.
Johnson et al., Amer. J. Repro. Immunol. (1981) 1:246-254.
Rettig et al., Int. J. Cancer (1985) 35:469-475.
Hole et al., "Trophoblast-Specific Glycoprotein Defined by Monoclonal Antibody 5T4," British Society for Immunology & British Transplantation Society 1986 Joint Annual Meeting, Nov. 12-14, 1986, abstract 66.
Stern et al., "Molecular Characterisation of Human Teratocarcinoma-Trophoblast Cell Surface Antigens," J. Repro. Immun., Supp:6 (Jun. 1986).
Anderson et al., "Monoclonal antibodies to human trophoblast and sperm antigens: Report of two WHO-sponsored workshops, Jun. 30, 1986--Toronto, Canada," J. Repro. Immun., 10:231-257 (1987).
Hole et al, "A 72 kD trophoblast glycoprotein defined by a monoclonal antibody", Br. J. Cancer, 57:239-246 (1988).
Cho et al., "Characterization of three monoclonal antibodies to membrane co-factor protein (MCP) of the complement system and quantification of MCP by radioassay," Clin. Exp. Immunol., 83:257-261 (1991).
Purcell, et al., "The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46," Immunology, 70: 155-161 (1990).

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