59079 and 12599, protein kinase family members and uses...

Details 59079 and 12599, protein kinase family members and uses... 59079 and 12599, protein kinase family members and uses...

2006-02-21

2006-02-21

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S252300, C435S320100, C435S006120, C536S023200

Reexamination Certificate

active

07001753

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 59079 and 12599 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 59079 or 12599 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 59079 or 12599 gene has been introduced or disrupted. The invention still further provides isolated 59079 and 12599 proteins, fusion proteins, antigenic peptides and anti-59079 and anti-12599 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

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Young, Paul, et. al., Obscurin, A Giant Sarcomeric Rho Guanine Nucleotide Exchange Factor Protein Involved in Sarcomere Assembly, vol. 154, No. 1, (Jul. 9, 2001), pp. 123-136.
Ohara, O., et. al., “Homo Sapiens mRNA for KIAA1639 Protein, Partial Cds,” Feb. 22, 2001, (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jul. 20, 2004]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>.GenBank Accession No. AB046859.
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