50 kilodalton antigen obtained from the intraerythrocytic phase

Details 50 kilodalton antigen obtained from the intraerythrocytic phase 50 kilodalton antigen obtained from the intraerythrocytic phase

1991-02-26

1994-02-15

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

435947, 530350, 530822, A61K 39002

Patent

active

052864839

ABSTRACT:
The invention concerns antigens from the intraerythrocytic phase of Plasmodium falciparum, namely: a protein of 50 kDa with an isoelectric point of 5.5 and a protein of 65 kDa separated by electrophoresis in reducing conditions into two polypeptides of 47 and 18 kDa, both appearing in the serum of patients infected by Plasmodium falciparum or in the culture medium of this microorganism during its intraerythrocytic phase, as well as a protein of 126 kDa synthesized during the nuclear multiplication phase during schizogony and localized on the periphery of the schizonts at the parasitophore vacuole level, precursor of the 50 kDa and 65 kDa proteins. Application of these proteins in the preparation of vaccines against malaria, and monoclonal antibodies corresponding to the assay of the antibodies of an immunized subject and assay of the antigens according to the invention during an attack of malaria.

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