Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1978-07-28
1981-05-19
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424267, C07D22126, C07D40506
Patent
active
042686733
ABSTRACT:
The invention is concerned with certain novel 6,7-benzomorphan derivatives having analgesic and/or morphine-antagonistic properties of the formula ##STR1## wherein each R is a lower alkyl group; R.sub.1 is a hydrogen atom, or an alkyl, haloalkyl, alkenyl, haloalkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, cycloalkylidenealkyl, aralkyl, heteroarylalkyl or heterocycloalkylalkyl group; R.sub.2 is a hydrogen atom or a hydroxy, alkoxy, alkoxyalkoxy or acyloxy group.
Such 6,7-benzomorphans may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. Methods for producing such 6,7-benzomorphan derivatives, and novel intermediates useful for such production are also disclosed and form part of the invention.
REFERENCES:
patent: 3138603 (1964-06-01), May
patent: 3764606 (1973-10-01), Akkerman et al.
patent: 3981874 (1976-09-01), Merz et al.
patent: 4010164 (1977-03-01), Langbein et al.
patent: 4032529 (1977-06-01), Wentland et al.
patent: 4087532 (1978-05-01), Merz et al.
Oh-Ishi, T., et al., J. Org. Chem., 39(10), 1347-1349 (1974).
Shriner, R. in Organic Reactions, (Adams et al., editors), John Wiley, New York, 1942, vol. 1, p. 2.
Posner, G., in Organic Reactions, (Bittman et al., editors), John Wiley, New York, 1972, vol. 19, pp. 25-32.
Akkerman Antony M.
VAN Leeuwen Geertruida C.
ACF Chemiefarma N.V.
Schwartz Richard A.
LandOfFree
5-Unsubstituted-9,9-dimethyl-6,7-benzomorphans does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-Unsubstituted-9,9-dimethyl-6,7-benzomorphans, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-Unsubstituted-9,9-dimethyl-6,7-benzomorphans will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1490947