5'-trifluoromethyl-2'-deoxy-uridine phospholipid compounds

Details 5'-trifluoromethyl-2'-deoxy-uridine phospholipid compounds 5'-trifluoromethyl-2'-deoxy-uridine phospholipid compounds

1991-05-16

1993-04-06

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1920

Patent

active

052005151

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each C.sub.16-18 long-chain aliphatic acyl and are the same or different; and pharmacologically acceptable salts thereof are disclosed. These novel compounds are effective against 5-FU-resistant tumor cells, have low toxicity, and are not inactivated by nucleoside phosphorylase in vivo.

REFERENCES:
patent: 4797479 (1989-01-01), Shuto et al.
Beres et al., "Synthesis and Antitumor and Antiviral Properties of 5-Halo- and 5-(Trifluoromethyl)-2'-Deoxyuridine 3',5'-Cyclic Monophosphates and Neutral Triesters", J. Med. Chem., vol. 29, No. 7, pp. 1243-1249, Jul. 1986.

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