5-Thiazole-methane-amines, and their use as antilipolytics

Details 5-Thiazole-methane-amines, and their use as antilipolytics 5-Thiazole-methane-amines, and their use as antilipolytics

1976-09-08

1978-08-22

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424251, 424267, 424270, 260302R, 26029368, 544238, 544369, 544333, C07D27738, A61K 31425

Patent

active

041089944

ABSTRACT:
A 5-thiazole-methane-amine selected from the group consisting of (1) compounds having the formula ##STR1## wherein R.sub.1 represents an alkyl having from 1 to 6 carbon atoms and R.sub.2 and R.sub.3 represent members selected from the group consisting of hydrogen, alkyl having from 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, and, taken together, alkylene having up to 5 carbon atoms, azaalkylene having up to 4 carbon atoms, alkylalkylene having up to 5 carbon atoms in the alkylene and 1 to 4 carbon atoms in the alkyl, and alkylazaalkylene having up to 4 carbon atoms in the azaalkylene and 1 to 4 carbon atoms in the alkyl which may be in any position, and (2) its acid addition salts with non-toxic, pharmaceutically-acceptible acids; as well as processes for the preparation of the compounds and a process for use of the compounds as an antilipolytic agent.

REFERENCES:
buchman et al., Chem. Abstracts, 39:1873 (1945).
Wagner et al., Synthetic Organic Chemistry, Wiley, N.Y., 1953, pp. 666-670 & 679-680.
Zubarovskii et al., Chem. Abstracts, 58:2525 (1963).

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