5-substituted uridine derivatives

Details 5-substituted uridine derivatives 5-substituted uridine derivatives

1992-10-19

1995-05-30

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2855, A61K 31505, C07H 1906

Patent

active

054201179

ABSTRACT:
This invention provides a 5-substituted uridine derivative of the formula ##STR1## wherein X is F or CF.sub.3, R.sub.1 and R.sub.2 each represent a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6) (wherein R.sub.4, R.sub.5 and R.sub.6 represent C.sub.1 -C.sub.10 alkyl or the like), OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group or carboxylalkylcarbonyloxy group, R.sub.3 is a group --OSi(R.sub.4)(R.sub.5)(R.sub.6), H, OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group, or carboxylalkylcarbonyloxy group, and at least one of R.sub.1, R.sub.2 and R.sub.3 is a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6), with the proviso that when X is fluorine atom, R.sub.3 is not hydrogen, and an intermediate for the preparation thereof, preparation processes of the derivative and anti-tumor agent containing the derivative as an active ingredient.

REFERENCES:
patent: 4334059 (1982-06-01), Ogilvie
patent: 4472386 (1984-09-01), Kodama et al.
patent: 4762823 (1988-08-01), Watanabe et al.
patent: 4871837 (1989-10-01), Magnusson et al.
patent: 4916121 (1990-04-01), Saneyoshi et al.
patent: 4992534 (1991-02-01), Fujii et al.
patent: 5198540 (1993-03-01), Koster

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