5-Substituted quinazolinone derivatives and compositions...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S287000, C546S189000, C546S348000

Reexamination Certificate

active

07635700

ABSTRACT:
Provided are 5-substituted quinazolinone compounds, for example, of formula (I), and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use for treating angiogenesis or cytokine related disorders, and pharmaceutical compositions of these compounds are disclosed.

REFERENCES:
patent: 5635517 (1997-06-01), Muller et al.
patent: 2003/0199530 (2003-10-01), Goldstein et al.
patent: WO 2004/103274 (2004-12-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
El-Fattah et al., “Synthesis and screening of some quinazolinone derivatives,” Bulletin of the Faculty of Pharmacy, Cairo University, 15:273-283 (1976).
Jonsson et al., “Chemical structure and teratogenic properties,”Acta Pharm. Suecica, 9:431-446 (1972).

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