5-substituted pyrimidine nucleosides and nucleotides

Details 5-substituted pyrimidine nucleosides and nucleotides 5-substituted pyrimidine nucleosides and nucleotides

1995-02-28

1996-11-19

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 282, 536 284, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, C07H 1900, C07H 1906

Patent

active

055764290

ABSTRACT:
The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections.

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