5-Substituted pyrimidine derivatives of conformationally...

Details 5-Substituted pyrimidine derivatives of conformationally... 5-Substituted pyrimidine derivatives of conformationally...

2006-03-07

2006-03-07

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S313000, C544S317000, C514S274000

Reexamination Certificate

active

07009050

ABSTRACT:
The embodiments described herein concern 5-substituted pyrimidine derivatives of conformationally locked nucleoside analogues and to the use of these derivatives as anti-viral and anti-cancer agents. The compounds are of the formula:wherein B is uracil-1-yl or cytosin-1-yl having a 5-substituent selected from halogen, alkyl, alkenyl, and alkynyl, with the proviso that where B is uracil-1-yl, the 5-substituent is not methyl. The compounds are useful in the treatment of Herpes simplex virus (HSV).

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