5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

Details 5-substituted pyrido[2,3-d]pyrimidine-2,4-diones 5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

1987-04-08

1989-02-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544311, C07D47104, A61K 31505

Patent

active

048085871

ABSTRACT:
The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a lower alkyl group; and each of R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

REFERENCES:
patent: 3272816 (1966-09-01), Papesch
McLean et al., J. Chem. Soc., p. 2582 (1949).
Tominaga et al., Chemical Abstracts, vol. 100, No. 209737y (1984).
Rodgers et al., Chemical Abstracts, vol. 106, No. 156415g (1987).
Matyus et al., Chemical Abstracts, vol. 102, No. 6405g (1985).

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