5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of us

Details 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of us 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of us

1985-04-05

1987-05-19

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514234, 514258, 544118, 544262, A61K 31415, C07D47104

Patent

active

046669086

ABSTRACT:
The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart failure or cardiac insufficiency. The novel compounds bind adenosine receptors and selectively inhibit phosphodiesterase.

REFERENCES:
patent: 3165520 (1965-01-01), Schmidt
patent: 3939161 (1976-02-01), Ratajczyk
Synthesis, p. 727 (1981).
Bull. Chem. Soc. Japan, 52 (1), 208 (1979).

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