5-Substituted picolinic acid derivatives and an anti-hypertensiv

Details 5-Substituted picolinic acid derivatives and an anti-hypertensiv 5-Substituted picolinic acid derivatives and an anti-hypertensiv

1979-03-23

1980-10-21

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 546 5, 546298, A61K 31455, C07D21379

Patent

active

042294487

ABSTRACT:
5-Substituted picolinic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R.sub.3 and R.sub.4, when taken together, represent a polymethylene chain; and R.sub.2 represents an --OM group wherein M represents a hydrogen, sodium, potassium, calcium, aluminium or magnesium atom, a straight or branched chain or cyclic alkoxy group having 1 to 6 carbon atoms, an aminoalkoxy group, a phenoxy group, a substituted phenoxy group, a 5-indanyloxy group, an acyloxyalkyloxy group having the formula ##STR3## wherein R.sub.5 represents a hydrogen atom or a methyl group and R.sub.6 represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, or an amino group represented by the formula ##STR4## wherein R.sub.7 and R.sub.8, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a phenyl group which are useful as anti-hypertensive agents, a process for preparing the above 5-substituted picolinic acid derivatives, and anti-hypertensive compositions containing the same.

REFERENCES:
patent: 3983126 (1976-09-01), Dufour
Maeda et al., Chemical Abstracts, vol. 81 (1974) 135,964k.
Endo et al., Chemical Abstracts, vol. 54 (1960) 24,705d.

Affiliated with

Also associated with

Rating

5-Substituted picolinic acid derivatives and an anti-hypertensiv does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-Substituted picolinic acid derivatives and an anti-hypertensiv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-Substituted picolinic acid derivatives and an anti-hypertensiv will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2022792