5-substituted ornithine derivatives

Details 5-substituted ornithine derivatives 5-substituted ornithine derivatives

1989-02-01

1990-02-20

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562561, A61K 31195

Patent

active

049027190

ABSTRACT:
This invention relates to ornithine derivatives substituted at the 5 position with an R group which can be a --CH.sub.2 F, --CHF.sub.2, --CHClF, --C.tbd.CH, --CH.dbd.CH.sub.2, or --CH.dbd.C.dbd.CH.sub.2 group and the pharmaceutically acceptable acid addition salts thereof which are specific inhibitors of OAT and can be used in the treatment of conditional deficiencies of ornithine.

REFERENCES:
patent: 4326071 (1982-04-01), Bey
patent: 4668703 (1987-05-01), Krantz
Daune, Biochem. J., 253(2), pp. 481-488 (7/1988).
Bey, J. Neurochem., 37(5), pp. 1341-1344 (1981).

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