5-Substituted indan-2 carboxylic acid and functional derivatives

Details 5-Substituted indan-2 carboxylic acid and functional derivatives 5-Substituted indan-2 carboxylic acid and functional derivatives

1977-12-14

1980-09-23

Myers, Jane S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260559R, 260558R, 250558A, 260558P, 260558S, 260556B, 260556C, 560 10, 560 21, 560 36, 560 51, 560 52, 562428, 562436, 562441, 562460, 562462, 424309, 424317, 424319, 424321, 424324, C07C 6520, C07C 6995, A61K 3119, A61K 31215

Patent

active

042243416

ABSTRACT:
5-Substituted indan-2-carboxylic acids and functional derivatives thereof having inflammation-reducing properties have the general formula ##STR1## in which R is a phenyl, phenyl-lower alkenyl, phenyl-lower alkyl, phenyl substituted by at least one of the halogens, lower alkyl, lower alkoxy, acetamido, amino, lower dialkylamino, nitro, phenyl, lower alkylsulfonyl, lower dialkylaminosulfonyl and sulfamido, cyclohexyl, furyl, lower alkylfuryl, thienyl, halothienyl, lower alkylthienyl, or pyridyl group and R' is a hydroxyl, lower alkoxy, lower dialkylaminoalkoxy, cinnamoylamido lower alkoxy, 2-hydroxyethylamino, amino or lower dialkylaminoalkyl amino group. Besides the esters and amides, the functional derivatives of the acids include the pharmacologically acceptable salts of the above compounds. The compounds are also of low toxicity, have analgesic activity and exert an antipyretic effect.

REFERENCES:
patent: 3953500 (1976-04-01), Noguchi et al.
patent: 4057573 (1977-11-01), Haas et al.
Kirsch et al., Ann. 1976, pp. 1914-1924.
Noguchi et al., Japan Kokai 74-80053, as cited in Chem. Abstracts 82, 15594f (1975).

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