5-Substituted indan-2-carboxylic acid and functional derivatives

Details 5-Substituted indan-2-carboxylic acid and functional derivatives 5-Substituted indan-2-carboxylic acid and functional derivatives

1978-01-27

1981-05-26

Siegel, Alan

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

424263, 424285, 549 79, 2603473, 2603474, 546342, B29H 304

Patent

active

042698480

ABSTRACT:
5-Substituted indan-2-carboxylic acids and functional derivatives thereof having inflammation-reducing properties have the general formula ##STR1## in which R is a phenyl, phenyl-lower alkenyl, phenyl-lower alkyl, phenyl substituted by at least one of the halogens, lower alkyl, lower alkoxy, acetamido, amino, lower dialkylamino, nitro, phenyl, lower alkylsulfonyl, lower dialkylaminosulfonyl and sulfamido, cyclohexyl, furyl, lower alkylfuryl, thienyl, halothienyl, lower alkylthienyl, or pyridyl group and R' is a hydroxyl, lower alkoxy, lower dialkylaminoalkoxy, cinnamoylamido lower alkoxy, 2-hydroxyethylamino, amino or lower dialkylaminoalkyl amino group. Besides the esters and amides, the functional derivatives of the acids include the pharmacologically acceptable salts of the above compounds. The compounds are also of low toxicity, have analgesic activity and exert an antipyretic effect.

REFERENCES:
patent: 3953500 (1976-04-01), Noguchi et al.
patent: 4057573 (1977-11-01), Haas et al.
Kirsch et al, Liebigs Ann. Chem., (1976), pp. 1914-1924.

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