5-substituted amino-4-hydroxy-pentanoic acid derivatives and the

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 18, 514 19, 530323, 530330, 530331, 530332, 548344, 560159, 564157, 564158, 564152, 564153, A61K 3743, C07K 506, C07K 508, C07K 510, C07D23364, C07C12506, C07C10319, C07C10300, C07C10320

Patent

active

048513873

ABSTRACT:
A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an N-protecting group, R.sup.2, R.sup.3 and R.sup.5 may be any of a variety of groups including the side chains of amino acid residues, R.sup.4 is a hydrogen atom or a lower alkyl group, R.sup.6 is a group which is substituted by one or two hydroxyl groups, and R.sup.7 is any of a variety of groups, including a hydroxyl group, which compounds are renin inhibitors useful as hypotensive drugs, are disclosed.

REFERENCES:
patent: 4729985 (1988-03-01), Kleinman et al.

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