5-substituted 3-aminoalkyl indoles useful in treatment of migrai

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548504, 548506, 548507, 548315, 514415, 546198, C07D20914, A61K 3140

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active

046720677

ABSTRACT:
Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents CHO, COR.sub.8, CO.sub.2 R.sub.8, CONR.sub.9 R.sub.10, CSNR.sub.9 R.sub.10 or SO.sub.2 NR.sub.9 R.sub.10, where

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Espamer, V., "Gramine Derivatives Antagonistic to 5-Hydroxy Tryptamine", Science vol. 121, pp. 369-370, (1955).
Shaw, et al., "New Agents Inhibitory to . . . Serotonin . . . ," Chem. Abst. 50:14127, (1955).
Shaw and Woolley, "Indole Carboxamidines and Amino-Methylindoles . . . ," J.A.C.S. 79:3561.
McOnic, L. F. W., Protective Groups in Organic Chemistry, Plenum Press, New York, (1973).
Hiremath, et al, "Aminotryptamines Analogous to Serotonin", Chem. Abst, 62:7717.

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