5-Substituted-3-aminoalkyl indole derivatives

Details 5-Substituted-3-aminoalkyl indole derivatives 5-Substituted-3-aminoalkyl indole derivatives

1987-03-26

1990-01-16

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548504, 548505, 548506, A61K 3140, C07D20914

Patent

active

048943878

ABSTRACT:
Compounds are disclosed of the general formula (I) ##STR1## wherein R.sub.1 represents halogen, alkyl, alkoxy or hydroxyl, or a group NR.sub.a R.sub.b or CON.sub.a R.sub.b, where R.sub.a and R.sub.b are hydrogen, alkyl or alkenyl or with the nitrogen atom form a saturated monocyclic 5 to 7-membered ring;

REFERENCES:
patent: 4785016 (1988-11-01), Evans
patent: 4816470 (1989-03-01), Dowle
Handbook of Experimental Pharmacology, vol. XIX, Springer-Verlag, New York, 1966.
A Manual of Pharmacology, Sollmann, 8th Ed., pp. 45-57.
Proposals for the Classification and Nomenclature of Functional Receptors and 5-Hydroxytryptamine, Neuropharmacology, vol. 25, No. 6, pp. 563-576, 1986.
Pharmacological Principles and Practice, Paton, pp. 1-2.
The Pharmacological Basis of Therapeutics, 7th Ed., pp. 35-37.
Evidence for Two Types of Excitatory Receptor for 5-Hydroxytryptamine in Dog Isolated Vasculature, Apperley, pp. 215-223, Re J. Pharmac, (1980).

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