5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their

Details 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their

1982-09-15

1984-03-06

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

549462, 549467, 549468, A61K 3134, C07D30785

Patent

active

044354223

ABSTRACT:
Described are compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently of one another denote hydrogen or loweralkyl; A is CO, CH.sub.2, O, S, SO or CHOH; X is hydrogen, halo, loweralkyl, or --CH.sub.2 NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are as defined above; W is COOR wherein R is hydrogen or alkyl of 1-10 carbon atoms, CH.sub.2 OH, CONR.sub.1 R.sub.2 or CH.sub.2 NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are as defined above; Z.sub.1 and Z.sub.2 independently of one another denote hydrogen, halo or loweralkyl; and pharmaceutically acceptable salts thereof.
The compounds are effective as diuretic agents.

REFERENCES:
patent: 4237144 (1980-12-01), Cragoe, Jr. et al.
patent: 4296122 (1981-10-01), Cragoe, Jr. et al.

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