5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III

Details 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III

1986-09-29

1988-11-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 23, 536 29, A61K 3170, C07H 1906, C07H 1910

Patent

active

047881810

ABSTRACT:
5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted 2',3'-dideoycytidine compounds have been found to be effective against HTLV-III/LAV virus.

REFERENCES:
patent: 3346562 (1967-10-01), Honjo et al.
patent: 3433783 (1969-03-01), Honja et al.
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 3891623 (1975-06-01), Vorbruggen et al.
Sigma Chemical Company Catalog, Feb. 1984.

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