Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-01-09
1996-09-03
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514331, 514428, 514213, 540582, 540585, 546192, 546229, 546233, 546234, 546236, 546237, 548566, 548570, 548571, 548575, C07D21106, A61K 31445, A61K 3146, A61K 3140
Patent
active
055524125
ABSTRACT:
Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
REFERENCES:
patent: 3234090 (1966-02-01), Huchner et al.
patent: 3274213 (1966-09-01), Lednicer
patent: 3277106 (1966-10-01), Bencze et al.
patent: 4133814 (1979-01-01), Jones et al.
Lednicer, Daniel, et al., J. Med. Chem. 10 78 (1967) "Mammalian Antifertility Agens. IV. Basic 3,4-Dihydronaphthalenes and 1,2,3,4-Tetrahydro-1-naphthols".
Bencze, W. L., et al., J. Med. Chem. 10 139 (1967) "Synthetic Estrogens, Implantation Inhibitors, and Hypocholesterolemic Agents. I. Tetrahydronaphthalene Series".
Lednicer, Daniel, et al., J. Med. Chem. 12 881 (1969) "Mammalian Antifertility Agents. VII. A Novel Sequence for the Preparation of 1,2-Disubstituted 3,4-Dihydronaphthalenes".
Jones, Robert C., Acta Endocrinologica (Copenh) 1987, 114:379-382 "The Effect of a Luteinizing Hormone-Releasing Hormone Antagonist on Experimental Endometriosis in the Rat".
Osteoporosis Conference, CRIP No. 1812/13 Apr. 16th/20th 1993. pp. 29-30.
Jones, Charles D., et al., J. Med. Chem. (1984) 27, 1057-1066 "Antiestrogens. 2. Structure--Activity Studies in a Series of 3-Aroyl-2-arylbenzo[b]thiophene Derivatives Leading to [6-Hydroxy-2-(4-hydroxyphenl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethox y]-phenyl]methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with Only Minimal Intrinsic Estrogenicity".
Chemical Abstracts, vol. 65, No. 3, Abstract 5425b, Aug. 1, 1966.
Cameron Kimberly O.
Dasilva Jardine Paul A.
Rosati Robert L.
Benson Gregg C.
Brokke Mervin E.
Davis Zinna Northington
Pfizer Inc
Richardson Peter C.
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