Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-06-01
1990-05-29
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514274, 544334, 544335, C07D40506
Patent
active
049296205
ABSTRACT:
Certain trans-6-[[(substituted)pyrimidin-5-yl]-ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
REFERENCES:
patent: 4677211 (1987-06-01), Jewell, Jr. et al.
Chemical Abstracts, vol. 111, No. 17, Abstract Nos. 153,827k, 153,830f, Oct. 23, 1989.
Chucholowski Alexander W.
Roth Bruce D.
Sliskovic Drago R.
Davis Zinna Northington
Lee Mary C.
Newtson Ruth H.
Warner-Lambert & Company
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