5-pyridyl-1,3-thiazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514318, 514342, 546280, 546256, 546194, 546270, 544124, 544360, C07D40514, A61K 3144

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active

046123210

ABSTRACT:
Novel compounds of the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted alkyl group, alkenyl group, aryl group, aralkyl group, cycloalkyl group, heterocyclic group having carbon as the bonding hand or amino group, R.sup.2 stands for a pyridyl group which may be substituted with alkyl group, and R.sup.3 stands for an optionally substituted aryl group or salts thereof, have analgesic, anti-piretic, anti-inflammatory and anti-ulcer actions, and can be administered to mammals for the therapy of pain, inflammatory diseases, rheumatic chronic diseases.

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Pendalwas et al., CA 97: 55722v, 1982.
Le Count et al., CA 87: 135172z, 1977.
Jpn Kokai Tokkyo Koho, CA 90: 181605c, 1979.
Reaction of 5-Chloropyridin-2-yl-thioureas with Phenacyl Bromides a New Thiazole Synthesis, J.C.S. Chem. Comm pp. 2282-2833, 1977, David J. Le Count.
N-(4-Substituted-thiazolyl)oxamic Acid Derivatives, a New Series of Potent, Orally Active Antiallergy Agents J. Med Chem. pp. 1158-1163, 1983 Hargrave et al.

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