Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-02
2007-10-02
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S270400
Reexamination Certificate
active
11354897
ABSTRACT:
An optionally N-oxidized compound represented by the formula:wherein R1represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R2represents an aromatic group, R3represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR4(R4represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A3receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A3receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.
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Hcaplus 130:75567.
Kanzaki Naoyuki
Miwatashi Seiji
Ohkawa Shigenori
Morris Patricia L.
Takeda Pharmaceutical Company Limited
Wenderoth , Lind & Ponack, L.L.P.
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