5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonic

Details 5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonic 5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonic

1980-11-24

1982-01-12

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546270, A61K 3144, C07D41304

Patent

active

043105319

ABSTRACT:
5-PY-benzoxazol-2(3H)-ones, cardiotonic agents, are prepared by reacting 2-amino-4-PY-phenol with a carbonylating agent, e.g., carbonyldiimidazole, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. 5-PY-benzoxazol-2(3H)-ones or pharmaceutically-acceptable acid-addition or cationic salts thereof are disclosed as active components in cardiotonic compositions for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment.

REFERENCES:
patent: 3682933 (1972-08-01), Engel
Coates et al., [J. Chem. Soc. 1943, 406].
Heilbron et al., [J. Chem. Soc. 1940, 1279].

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