5-(Pyridinyl)-1H-pyrazolo[3,4-b] pyridines and their cardiotonic

Details 5-(Pyridinyl)-1H-pyrazolo[3,4-b] pyridines and their cardiotonic 5-(Pyridinyl)-1H-pyrazolo[3,4-b] pyridines and their cardiotonic

1981-09-28

1983-03-01

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546119, C07D48704, A61K 3144

Patent

active

043754678

ABSTRACT:
1-R-3-R'-5-PY-1H-pyrazolo[3,4-b] pyridines (I) or acid-addition salts thereof, which are useful as cardiotonics, are prepared by reacting a .alpha.-PY-.beta.dimethylamino-acrolein with 5-amino-1-R-3-R'-1H-pyrazole, where R is lower-alkyl or lower-hydroxyalkyl, R' is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. Also shown are cardiotonic compositions and method for increasing cardiac contractility using said compounds (I) or pharmaceutically acceptable acid-addition salts thereof.

REFERENCES:
patent: 3403158 (1968-09-01), Markillie
Chemical Abstracts 80: 27117g (1974).
Chemical Abstracts vol. 87, item 39, 357t, 1977.
Balicki, Roman; Kaczmarek, Lukasz; Nantka-Namirski, Pawel (Inst. Org. Chem., Pol. Acad. Sci., Warsaw, Pol.) Acta Pol. pharm. 1976, 33(3), 289-93 (Pol.)and English Translation.

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