5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as

Details 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as

1980-03-17

1981-04-28

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546119, 546257, 546258, C07D47102, A61K 31415

Patent

active

042646030

ABSTRACT:
1-R-5-PY-6-Q-1H-pyrazolo[3,4-b]pyridin-3-amines or pharmaceutically-acceptable acid-addition salts thereof, which are useful as cardiotonics, are prepared by reacting a 2-halo-5-PY-6-Q-nicotinonitrile with 1-R-hydrazine, where R is hydrogen, lower-alkyl, lower-hydroxyalkyl, 2,3-dihydroxypropyl or lower-alkoxyalkyl, Q is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. Also shown are cardiotonic compositions and method for increasing cardiac contractility using said compounds or salts.

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patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
C.A.; 87, (1977), 39357t, Balicki et al.
Balicki et al.; Acta Poloniae Pharmaceutica, (1976), vol. 33 (3), pp. 289-293.
Nantka-Namirski et al.; Pol. J. Pharmacol. Pharm., (1978), vol. 30, pp. 707-712.

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