5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-

Details 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2- 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-

1980-12-29

1982-06-15

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546271, 548305, A61K 3146, C07D48702

Patent

active

043351328

ABSTRACT:
5-(Py-Y)-1H-benzimidazol-2-ol or 5-(Py-Y)-1H-benzimidazole-2-thiol or lower-alkyl ethers or thioethers thereof or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonics, are prepared by reacting 4-(Py-Y)-1,2-benzenediamine with urear or carbonyldiimidazole to produce 5-(Py-Y)-1H-benzimidazol-2-ol or with thiourea, an alkali metal lower-alkyl xanthate or thiocarbonyldiimidazole to produce 5-(Py-Y)-1H-benzimidazole-2-thiol and by reacting 5-(Py-Y)-1H-benzimidazole-2-thiol with a lower-alkylating agent to produce 2-(lower-alkylthio)-5-(Py-Y)-1H-benzimidazole. 2-(Lower-alkoxy)-5-(Py-Y)-1H-benzimidazole is prepared by reacting 4-(Py-Y)-1,2-benzenediamine with tetra-(lower-alkoxy)methane.

REFERENCES:
patent: 3338916 (1967-08-01), Hunziker
patent: 3842098 (1974-10-01), Scherhag et al.
patent: 3907822 (1975-09-01), Narayanan
patent: 3914310 (1975-10-01), Frick et al.
patent: 3920683 (1975-11-01), Porret et al.
patent: 4026936 (1977-05-01), Lauer et al.
Chemical Abstracts, vol. 77, abst. No. 141,468k (1972), (abst. of Zubarovakii et al., Khim Geterotskl. Soedin, 1972 (5), pp. 687-690 (Russ.).

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