5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine

Details 5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine 5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine

1990-10-16

1992-04-14

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546171, C07D40704, C07D40904, A61K 3138, A61K 3147

Patent

active

051048850

ABSTRACT:
Improvement in the treatment of malaria has been demonstrated with 5-[(aryl)alkoxy] primaquine compounds and 5[(heterocycle)alkoxy] primaquine compounds. These primaquine related compounds are effective in malarial chemotherapy. The 5-arylalkoxy primaquine compounds of the invention are at least as effective in malarial treatment as the prior are 5-alkoxy primaquine compounds, but are not as toxic as the 5-alkoxy compounds at higher dosage ranges. The 5[(heterocycle)alkoxy] primaquine compounds show less toxicity than primaquine in blood schizonticidal studies and are comparable to the 5-arylalkoxy primaquine compounds in efficacy.

REFERENCES:
patent: 1938047 (1933-12-01), Schonhofer et al.
patent: 2477479 (1949-07-01), Elderfield
patent: 3948920 (1976-04-01), Nabih
patent: 4209519 (1980-06-01), Kinnamon
patent: 4431807 (1984-02-01), Strube et al.
patent: 4554279 (1985-11-01), Saggiomo et al.

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