5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase...

Details 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase... 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase...

2011-08-16

2011-08-16

Young, Shawquia (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S196000

Reexamination Certificate

active

07998990

ABSTRACT:
The present invention concerns a compound of formula Ia wherein: Ra*is hydrogen or C1-C4-alkyl; Rb*is —(C1-C4-alkylene)-Y—C1-C4-haloalkyl or —(C1-C4-alkylene)-Y—C1-C4-hydroxyalkyl; Y represents —CONH— or a five membered heteroaryl group. R2*is C1-C4-alkyl or halogen; R3*is halo, —SO2—CH3, —SO2—CF3, carboxy, —CO—NH2, —CO-di(C1-C8-alkyl)amino, or a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by halo, cyano, oxo, hydroxy, carboxy, nitro, C3-C8-cycloalkyl, C1-C8-alkylcarbonyl, C1-C8-alkoxy optionally substituted by aminocarbonyl, or C1-C8-alkyl optionally substituted by hydroxy, C1-C8-alkoxy, C1-C8-alkylamino or di(C1-C8-alkyl)amino; R4*is hydrogen, halo, —SO2—CH3, nitrile, C1-C8-haloalkyl, imidazolyl, C1-C8-alkyl, —NR8*R9*, or —SO2—NR8*R9*; and R5*is hydrogen, halogen or C1-C8-alkyl; R8*and R9*are independently hydrogen, amino, C1-C8-alkylamino, di(C1-C8-alkyl)amino, or CC1-C8-alkyl optionally substituted by hydroxyl; or a pharmaceutically acceptable salt, or solvate thereof, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase.

REFERENCES:
patent: WO 03/072557 (2003-09-01), None
patent: WO 2005/021519 (2005-03-01), None
patent: WO 2007/068473 (2007-06-01), None
Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Science (1999), vol. 286, 531-537.
Cancer [online], [retrieved on Jul. 6, 2007]. Retrieved from the internet, URL http://www.nlm.nih.gov/medlineplus/cancer.html>.
Cancer [online], [retrieved on Jul. 6, 2007]. Retrieved from the internet, URL; http://en.wikipedia.org/wiki/Cancer.
Vippagunta, et al. Advanced Drug Delivery Reviews 48 (2001) 3-26.
Rheumatoid arthritis [online] retrieved on Aug. 14, 2010. (URL:http://www. medicinenet.com/rheu matoid—arth ritis/article, htm>).
Diabetes [online] retrieved on Apr. 15, 2009 from the internet [http:||www.merck.com/mmpe/print/sec121ch1581ch158b.html].
Asthma [online] retrieved on Oct. 23, 2010 from the internet (URL; https://health.google.com/health/ref/Asthma.
Chronic obstructive pulmonary disease [online] retrieved on Oct. 23, 2010 from the internet (URL; http://www.nlm.nih.gov/medlineplus/ency/article/000091.htm).

Affiliated with

Also associated with

Rating

5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2668465