5-(Phenyl or benzyl amino)methyl-pyrrolo[2,3-d]pyrimidin-4-one

Details 5-(Phenyl or benzyl amino)methyl-pyrrolo[2,3-d]pyrimidin-4-one 5-(Phenyl or benzyl amino)methyl-pyrrolo[2,3-d]pyrimidin-4-one

1982-09-24

1984-03-06

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424 11, 424251, C07D48704, A61K 31505, A61K 4300

Patent

active

044355700

ABSTRACT:
Novel 7-deazapurine derivatives of the formula: ##STR1## wherein X is halogen, Y is hydroxyl or di-C.sub.1-3 alkylamino, Z is a --NH-- or --NHC(.dbd.NH)-- group, l is an integer of 1 to 5, m is an integer of 0 to 2, and n is 1 when Z is a --NH-- group or n is 0 or 1 when Z is a --NHC(.dbd.NH)-- group, and salts thereof are selectively taken up by tumor cells.

REFERENCES:
patent: 3598824 (1971-08-01), Troxler et al.
patent: 3657245 (1972-04-01), Borman et al.
patent: 4229453 (1980-10-01), Roth et al.
S. Nishimura et al., GANN Monograph on Cancer Research, 24, 245-262 (1979).
J. R. Katze et al., Biochem. Biophys. Res. Comm., 96, 313-319 (1980).

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