5-phenyl-2-furan ketones and use as antiepileptic agents

Details 5-phenyl-2-furan ketones and use as antiepileptic agents 5-phenyl-2-furan ketones and use as antiepileptic agents

1989-06-23

1992-02-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514326, 514374, 514422, 514461, 514471, 544152, 544379, 546214, 548215, 548517, 549483, 549488, B61K 3134, C07D30746

Patent

active

050914260

ABSTRACT:
A method of preventing epileptic seizures in a human or lower animal subject susceptible to said seizures, comprising systemically administering to said subject a safe and effective amount of a compound of the formula: ##STR1## wherein (a) X is halo or nil, and Y is a substituent selected from the group consisting of unsubstituted or halogen-substituted methyl, halo, nitro, amino, and methoxy; and

REFERENCES:
patent: 3856825 (1974-12-01), Wright et al.
patent: 4031113 (1977-06-01), Pelosi
patent: 4035394 (1977-07-01), Pelosi et al.
patent: 4085118 (1978-04-01), Pelosi
Oleinik, A. F. et al., "Amino- and Hydroxaminoderivatives of Arylfurans", Khimia Geterotsiklicheskikh Soedinentii 11:1448-1452, 1972.
Goldenberg, M., "F-461, 3-diethylamino-2,2-dimethylpropyl 5-(P-nitrophenyl)-2-furoate hydrochloride, a new non-anticholinergic spasmolytic and a gastric acid inhibitor", Arch. Int. Pharmacodyn, vol. 222, pp. 27-39 (1976).
Oleinik, A. F. et al., "Synthesis and Tuberculostatic Activity of 5-arylpyromucic acid derivatives", Pharmaceutical Chemical Journal, vol. 10, No. 4 (Apr. 1976), pp. 463-465.
Olenik et al, C.A. vol 78 (1973), 43109q.

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