Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-02-27
1979-11-06
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
2605708R, 424309, 424311, 424319, 424330, A61K 31275, A61K 3124, A61K 31195, A61K 31135
Patent
active
041736494
ABSTRACT:
5-Phenyl-2,4-pentadien-1-amines and salts thereof are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, nitro, cyano, amino, carboxy or lower alkoxycarbonyl, and R.sup.2 and R.sup.3 are the same or different and are hydrogen, lower alkyl, alkenyl-lower alkyl, aralkyl, and substituted lower alkyl. These compounds possess useful pharmceutical activites due to their ability to inhibit the prostaglandin-inactivating enzyme 15-.alpha.-hydroxyprostaglandin dehydrogenase.
REFERENCES:
patent: 3094561 (1963-06-01), Sundeen et al.
Dimmock et al.-J. of Pharm. Sci., vol. 63, #1, Jan. 1974, pp. 69-74; vol. 65, #4, Apr. 1976, 483-8.
Gschwend et al., J. Org. Chem. 38, 2169 (1973).
Peskar et al.-J. Pharm. Pharmac., 1976, 28, 146.
Dejneka Tamara
Hauck Frederic P.
Sundeen Joseph E.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Rodney Burton
Waddell Frederick E.
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