Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-05-23
1989-10-31
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548427, 548577, A61K 3140, C07D20960, C07D20706, C07D20708
Patent
active
048778079
ABSTRACT:
A 5-phenyl-1,3,3a,4,5,9b-hexahydro-3H-benz(e)indole compound of the formula I: ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen or C.sub.1-3 alkyl in the 3a- or 4-position, R.sup.3 and R.sup.4 are each hydrogen, hydroxyl, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or trifluoromethyl, acetylamino or amino and R.sup.5 is hydrogen or C.sub.1-3 alkyl, or a salt thereof with a physiologically tolerated acid. The compounds and compositions are useful for treating depression or trating convulsions and which exhibit a sedative and tranquilizing effect when administered to a patient.
REFERENCES:
patent: 4595688 (1986-06-01), Maryanoff
patent: 4678791 (1987-07-01), Napier
patent: 4719216 (1988-01-01), Maryanoff
Buschmann Ernst
Himmele Walter
Steiner Gerd
Teschendorf Hans-Juergen
Weifenbach Harald
BASF - Aktiengesellschaft
Berch Mark L.
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