5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pen

Details 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pen 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pen

1995-08-24

1997-03-25

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, 536 267, 536 2671, 536 268, 536 2762, 536 2781, 536 2851, C07H 1906, C07H 1910, C07H 1916, C07H 1920, C07H 2100

Patent

active

056146221

ABSTRACT:
The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more mild conditions than existing methods. The invention further provides a nucleoside base protective group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protective groups, as well as nucleoside synthons having such base protective groups.

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