Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-12-09
2000-09-19
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 9131, 435325, 435352, 4353201, 536 231, 536 232, 536 235, 536 243, 536 2431, 536 245, C12Q 168, C12N 1511, C12N 1585, C07H 2104
Patent
active
061209937
ABSTRACT:
The present invention is directed to isolated nucleic acid molecules encoding mammalian 5-oxoprolinase (m 5-OPase). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of m 5-OPase in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify m 5-OPase function, and a method for isolating other m 5-OPase molecules. DNA oligomers and antibodies specific for m 5-OPase are provided, each of which can be used to detect m 5-OPase in a sample.
REFERENCES:
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Breslow Esther
Meister, deceased Alton
Meister, executor by Kenneth
Ye Guo-jie
Brusca John S.
Cornell Research Foundation Inc.
McGarry Sean
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