5-Oxa-13,14-didehydro-11-deoxy-17-phenyl-18,19,20 trinor-PGE.sub

Details 5-Oxa-13,14-didehydro-11-deoxy-17-phenyl-18,19,20 trinor-PGE.sub 5-Oxa-13,14-didehydro-11-deoxy-17-phenyl-18,19,20 trinor-PGE.sub

1977-08-01

1978-09-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560121, 562463, C07C17700

Patent

active

041139623

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
derwent Abstract 4723U-B DT-2305044-Q, (Sep. 8, 1973).
Derwent Abstract 18176Y/11 BE 846-080, (Oct. 3, 1977).
Derwent Abstract 61891X/33 DT 2603-172, (May 8, 1976).
Derwent Abstract 59715X/32 BE 839-533, (Jan. 7, 1976).
Derwent Abstract 79219X/42 US 3984,400, (May 10, 1976).

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