[5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use the

Details [5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use the [5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use the

1983-07-28

1985-03-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544331, A61K 31505, C07D40104

Patent

active

045044821

ABSTRACT:
N-R-N'-R'-N-[4(or 5)-PY-2-pyrimidinyl]ureas (I) or salts thereof, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, R' is hydrogen or methyl and R is methyl or ethyl when PY is attached to the 4-position of the pyrimidine ring or R is hydrogen, ethyl or n-butyl when PY is attached to the 5-position of the pyrimidine ring are useful as cardiotonic agents. The preparations of I and their cardiotonic use are shown.

REFERENCES:
patent: 4008235 (1977-02-01), Lesher et al.
Lesher, Singh and Mielens, [J. Med. Chem., 25(7), 837-842, (1982)].
Bennett et al., Journal of Medicinal Chemistry, 1978, vol. 21, No. 7, pp. 623-627.

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